5-Amino-1MQ 50mg/capsule, 60 caps
5-Amino-1MQ 50mg/capsule, 60 caps
5-Amino-1MQ (5-Amino-1-methylquinolinium iodide) is a selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in nicotinamide methylation and cellular methyl-donor utilization pathways.
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Overview
5-Amino-1MQ (5-Amino-1-methylquinolinium iodide) is a selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in nicotinamide methylation and cellular methyl-donor utilization pathways.
By inhibiting NNMT activity, 5-Amino-1MQ modulates enzymatic processes associated with nicotinamide metabolism, methylation network regulation, and intracellular cofactor-associated signaling systems.
Experimental investigations have examined the relationship between NNMT inhibition and regulatory pathways involving nicotinamide turnover, methylation dynamics, transcriptional control mechanisms, and downstream signal transduction processes.
Its well-characterized pharmacological profile has established 5-Amino-1MQ as a valuable research tool for studying NNMT enzyme biology, enzyme-inhibitor interactions, methylation pathway regulation, nicotinamide-associated metabolic networks, and structure-activity relationships involving NNMT-targeting compounds. Research applications include NNMT pharmacology, methyltransferase signaling studies, enzymatic regulation investigations, and mechanistic evaluation of nicotinamide methylation pathways.
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- Independently Lab Tested
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- For Laboratory Research Use Only
Properties
| Chemical Formula | C10H11N2+ |
|---|---|
| Synonyms | 5-amino-1-methylquinolinium, SCHEMBL6403148 CHEMBL4116828, ZINC552049, STL196667 |
| Molar Mass | 159.21 g/mol (cation) |
| CAS Number | 42464-96-0 (iodide reference) |
| PubChem CID | 950107 |
| Total Compound Content | 3,000 mg (50 mg per capsule) |
| Shelf Life | 36 months |
Swisschems identifies the product as 5-amino-1-methylquinolinium iodide. The linked laboratory report for lot RC0226-NC (2 October 2026) explicitly reports “5-amino 1mq w Iodide”. This finding refers to that tested sample; other linked reports do not all specify the counterion. The front label shows the cation only. The nominal 50 mg per capsule is retained: the available documentation does not clearly state whether this amount refers to the cation or the whole salt.
| Cation (front label) | C10H11N2+ · 159.21 g/mol · PubChem CID 950107 |
|---|---|
| Iodide salt (manufacturer reference) | C10H11IN2 · 286.11 g/mol · CAS 42464-96-0 · PubChem CID 66522933 |
Research
5-Amino-1MQ is a quaternary ammonium compound and selective inhibitor of nicotinamide N-methyltransferase (NNMT), a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide. By modulating NNMT activity, 5-Amino-1MQ influences enzymatic pathways associated with nicotinamide metabolism, methyl-donor utilization, and intracellular cofactor-associated regulatory networks. Experimental investigations have examined the relationship between NNMT inhibition and signaling pathways involving nicotinamide turnover, NAD+-associated metabolic systems, SIRT1-linked regulatory mechanisms, and transcriptional control processes. Additional studies have characterized the effects of NNMT inhibition on methylation pathway dynamics, enzyme-regulated signaling networks, and cellular regulatory systems influenced by nicotinamide metabolism. These characteristics have established 5-Amino-1MQ as a valuable research tool for investigating NNMT enzyme biology, enzyme-inhibitor interactions, methylation pathway regulation, nicotinamide-associated signaling processes, and mechanistic aspects of methyltransferase pharmacology. Supplied in 50 mg capsules. Independently third-party HPLC-tested; COA available per batch.Lab Results
Results refer to the tested sample. Check the batch and date in the report.
FAQ
What enzyme does 5-Amino-1MQ inhibit?
5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT), a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide. Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology.
How does 5-Amino-1MQ differ from compounds such as NMN and NR in pathway research?
NMN and NR are commonly studied in relation to nicotinamide-associated metabolic pathways, whereas 5-Amino-1MQ acts through selective inhibition of NNMT. This distinct mechanism makes 5-Amino-1MQ a useful research tool for examining enzymatic regulation of nicotinamide turnover, methylation pathway dynamics, enzyme-inhibitor interactions, and regulatory processes associated with NNMT activity.
Comparative investigations frequently utilize these compounds to explore different aspects of nicotinamide-related biochemical networks.
Why is 5-Amino-1MQ widely used in NNMT research?
5-Amino-1MQ possesses a well-characterized pharmacological profile and high selectivity for NNMT, making it a valuable reference compound for studies involving NNMT enzyme biology, methyltransferase pathway regulation, structure-activity relationships, and inhibitor-target interactions. Its established mechanism of action continues to support mechanistic investigations into nicotinamide methylation pathways and the broader role of NNMT within cellular regulatory networks.
Capsule excipients are not specified in the available product documentation.
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