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IGF-1 DES 1 mg

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IGF-1 DES 1 mg

IGF-1 DES 1 mg

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Livraison gratuite dès €99 d’achat. USPS Regular Shipping: €11,95 · FedEx 2 Days Delivery: €28,99 · FedEx Overnight Delivery: €40,99 Informations de livraison

IGF-1 DES (Des(1-3)IGF-1) is a naturally occurring, endogenous truncated form of IGF-1 lacking the first three N-terminal amino acids.

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Moyens de paiement acceptés
Livraison gratuite dès €99 d’achat. USPS Regular Shipping: €11,95 · FedEx 2 Days Delivery: €28,99 · FedEx Overnight Delivery: €40,99 Informations de livraison

-25% sur tout – jusqu’au 31 octobre
25% sur les prix habituels, en remplacement des autres soldes. Cumulable uniquement avec la remise crypto.

Présentation

IGF-1 DES (Des(1-3)IGF-1) is a naturally occurring, endogenous truncated form of IGF-1 lacking the first three N-terminal amino acids. This truncation reduces IGFBP affinity by approximately 10-fold relative to native IGF-1 while modestly increasing IGF-1 receptor binding potency.

The shorter half-life and higher local potency of IGF-1 DES make it a useful research tool for studying IGF-1R activation dynamics distinct from the longer-acting IGF-1 LR3 analogue.

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  • Research Grade Quality
  • For Laboratory Research Use Only
All SwissChems products are independently third-party tested at a USA-based HPLC-licensed laboratory prior to distribution. Certificates of Analysis (COA) are published on the Independent Test Results page and available at product level. If any independently conducted HPLC test returns a negative result, SwissChems will refund: (1) the cost of the HPLC test, and (2) the full order amount including shipping.

Propriétés

Chemical Formula C319H501N91O96S7
Synonyms IGF1 Human Des1-3; Insulin-Like Growth Factor 1 Des (1-3) Human Recombinant; Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Des(1-3); Des1-3; Des 1-3; Des (1-3); IGF-1 (4-70); IGF1 Des1-3
Molar Mass 7,649 g/mol
CAS Number 112603-35-7
Total Compound Content 1 mg per vial
Shelf Life 36 months

Recherche

IGF-1 DES is a truncated analogue of insulin-like growth factor 1 (IGF-1) in which the three N-terminal amino acids are absent relative to the full-length peptide. This structural modification alters its interaction profile with insulin-like growth factor binding proteins (IGFBPs), resulting in a greater proportion of unbound peptide available for receptor interaction. IGF-1 DES retains high-affinity binding to the insulin-like growth factor 1 receptor (IGF-1R) and preserves activation of downstream receptor-mediated signaling pathways, including PI3K/Akt/mTOR and MAPK/ERK cascades. The modified structure and distinct receptor-accessibility profile make IGF-1 DES a valuable research tool for investigating IGF-1R pharmacology, ligand-receptor interactions, growth factor signaling mechanisms, and comparative studies of IGF-1 analogues. Supplied as a lyophilized preparation (1 mg/vial). Independently third-party HPLC-tested; COA available per batch.

FAQ

How does IGF-1 DES differ from IGF-1 LR3 in terms of receptor interaction characteristics?

IGF-1 DES and IGF-1 LR3 are structurally modified forms of IGF-1 that differ in their interactions with insulin-like growth factor binding proteins (IGFBPs) and their resulting receptor-accessibility profiles. IGF-1 DES utilizes N-terminal truncation, whereas IGF-1 LR3 incorporates amino acid substitution and sequence extension.

These structural differences make both compounds useful research tools for investigating IGFBP interactions, ligand-receptor dynamics, and comparative IGF-1 receptor pharmacology.

What distinguishes IGF-1 DES from full-length IGF-1?

IGF-1 DES is a truncated analogue of IGF-1 in which the N-terminal region has been modified relative to the full-length peptide. This structural change alters its interaction characteristics while preserving high-affinity binding to the insulin-like growth factor 1 receptor (IGF-1R).

As a result, IGF-1 DES is frequently used in studies examining structure-function relationships, receptor activation mechanisms, and the influence of peptide architecture on growth factor signaling pathways.

Why is IGF-1 DES useful for growth factor signaling research?

IGF-1 DES retains activation of key IGF-1R-mediated signaling pathways, including PI3K/Akt/mTOR and MAPK/ERK regulatory cascades. Its modified structure and distinct interaction profile make it a valuable research tool for investigating ligand-receptor interactions, growth factor signaling mechanisms, receptor pharmacology, and comparative studies of IGF-1 analogues and related signaling systems.

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